吸入的聚集态67Ga2O3颗粒在比格犬、Fischer-344大鼠和CD-1小鼠体内的沉积与滞留情况。

Deposition and retention of inhaled aggregate 67Ga2O3 particles in beagle dogs, Fischer-344 rats, and CD-1 mice.

作者信息

Wolff R K, Kanapilly G M, Gray R H, McClellan R O

出版信息

Am Ind Hyg Assoc J. 1984 Jun;45(6):377-81. doi: 10.1080/15298668491399974.

Abstract

Deposition and retention of inhaled 67Ga2O3 aerosols were measured in ten beagle dogs to provide reasonable estimates for human deposition and in Fischer-344 rats and CD-1 mice to estimate lung burdens in small animals frequently used in toxicological evaluations. Aggregated particles of 67Ga2O3, 0.1 micron mass median diameter (MMD), were produced using heat treatment of 67Ga tetramethylheptanedione. Whole-body counting and gamma camera imaging were used to measure deposition. Pulmonary deposition in dogs was measured as 25% of the inhaled particles for the 0.1 micron particles. Tracheobronchial and nasopharyngeal deposition were much lower, 7% and 7% respectively. Pulmonary deposition of 0.1 micron (MMD) particles was calculated as 10% and 11% of inhaled particles in Fischer-344 rats and 15 and 20% in mice for two separate nose-only exposures of each species.

摘要

在十只比格犬中测量了吸入的67Ga2O3气溶胶的沉积和滞留情况，以便对人类沉积情况做出合理估计；同时也在Fischer-344大鼠和CD-1小鼠中进行了测量，以估计毒理学评估中常用的小型动物的肺部负荷。使用67Ga四甲基庚二酮的热处理制备了质量中值直径（MMD）为0.1微米的67Ga2O3聚集颗粒。采用全身计数和伽马相机成像来测量沉积情况。对于0.1微米的颗粒，犬类肺部沉积量测量为吸入颗粒的25%。气管支气管和鼻咽部的沉积量则低得多，分别为7%和7%。对于每个物种的两次单独仅经鼻暴露，0.1微米（MMD）颗粒在Fischer-344大鼠中的肺部沉积量计算为吸入颗粒的10%和11%，在小鼠中为15%和20%。