Muensch H, Maslow W C
Am J Clin Pathol. 1984 Jul;82(1):89-92. doi: 10.1093/ajcp/82.1.89.
The interference of O.C.T. (Optimum Cutting Temperature) embedding compound with the determination of estrogen and progesterone receptor analysis in rabbit uterus cytosol and human breast cancer tissue was investigated. It was determined that O.C.T. Compound reduces binding in rabbit uterus cytosol at concentrations greater than 1%. Hormone receptor binding greatly was reduced in human breast cancer tissues from O.C.T. embedded tissues when compared with the untreated tissue of the same patients. Progesterone receptor binding was affected more strongly than estrogen binding.
研究了最佳切割温度（O.C.T.）包埋剂对兔子宫胞浆和人乳腺癌组织中雌激素和孕激素受体分析测定的干扰。结果表明，当浓度大于1%时，O.C.T.包埋剂会降低兔子宫胞浆中的结合。与同一患者的未处理组织相比，O.C.T.包埋组织中的人乳腺癌组织激素受体结合显著降低。孕激素受体结合比雌激素结合受到的影响更强。
