Stanton B F, Baltimore R S, Clemens J D
Am J Dis Child. 1984 Aug;138(8):720-5. doi: 10.1001/archpedi.1984.02140460012006.
The decade of the 1970s was marked by an increased survival of children with complex heart lesions, use of prosthetic material in open heart surgery, and placement of indwelling central catheters in critically ill patients. We analyzed all 26 cases of children with infective endocarditis (IE) seen at Yale University, New Haven, Conn, from 1970 through 1979 to determine whether these and other factors resulted in a change in pediatric IE. A larger proportion of cases arose postoperatively as compared with previous series. Among the postsurgical and catheterization-related cases, the most common infecting agents were streptococci, not the expected staphylococci. Although the number of cases was small, IE associated with prosthetic material had a favorable prognosis; all survivors of IE with prosthetic material were cured by medical regimens alone. The IE cases in children with previously normal hearts were associated with indwelling central catheters.
20世纪70年代的特点是患有复杂心脏病变的儿童存活率提高、心脏直视手术中使用人工材料以及在重症患者中放置留置中心静脉导管。我们分析了1970年至1979年在康涅狄格州纽黑文市耶鲁大学就诊的所有26例儿童感染性心内膜炎（IE）病例，以确定这些因素及其他因素是否导致了儿童IE的变化。与先前的系列病例相比，术后出现的病例比例更大。在与手术和导管插入相关的病例中，最常见的感染病原体是链球菌，而非预期的葡萄球菌。尽管病例数量较少，但与人工材料相关的IE预后良好；所有患有与人工材料相关的IE的幸存者仅通过药物治疗方案就得以治愈。先前心脏正常的儿童中的IE病例与留置中心静脉导管有关。
