Berkowitz G S, Kelsey J L, LiVolsi V A, Holford T R, Merino M J, Ort S, O'Connor T Z, Goldenberg I S, White C
Am J Epidemiol. 1984 Jul;120(1):87-96. doi: 10.1093/oxfordjournals.aje.a113878.
The association between use of oral contraceptives and fibrocystic breast disease was assessed among women aged 20-74 years in a hospital-based case-control study conducted between November 1979 and November 1981 in Connecticut. The study groups comprised 633 women with biopsy-proven fibrocystic breast disease and 1,062 controls who had been admitted, as inpatients or outpatients, to general surgical services. For the premenopausal women, there was no evidence that long-term use of oral contraceptives was associated with a decreased frequency of fibrocystic breast disease among either current or past users. For the postmenopausal women, previous oral contraceptive exposure was associated with an increased occurrence of cystic disease. These findings contradict previous investigations reporting a negative association between oral contraceptive use and the development of fibrocystic breast disease.
1979年11月至1981年11月在康涅狄格州开展了一项基于医院的病例对照研究，对20至74岁女性口服避孕药与纤维囊性乳腺病之间的关联进行了评估。研究组包括633名经活检证实患有纤维囊性乳腺病的女性和1062名作为住院或门诊患者接受普通外科治疗的对照者。对于绝经前女性，没有证据表明长期使用口服避孕药与当前或既往使用者中纤维囊性乳腺病的发病率降低有关。对于绝经后女性，既往口服避孕药暴露与囊性疾病的发生率增加有关。这些发现与之前报道口服避孕药使用与纤维囊性乳腺病发生呈负相关的调查结果相矛盾。
