Quebbeman E J, Hamid A A, Hoffman N E, Ausman R K
Am J Hosp Pharm. 1984 Jun;41(6):1153-6.
The stability of fluorouracil when prepared and stored in plastic containers used for continuous infusion in home therapy was studied. Fluorouracil was diluted with 5% dextrose injection. Samples were stored for 16 weeks at 5 degrees C and room temperature in polyvinyl chloride drug reservoirs and at 5 degrees C in elastomeric balloons used in a disposable drug pump. Periodically, samples were tested by a stability-indicating high-performance liquid chromatography (HPLC) assay. At 5 degrees C, there was no significant degradation. At room temperature, there was a progressive increase in fluorouracil concentration, presumably because of evaporation of water. A 10% change in the fluorouracil concentration over 55 days was predicted. Fluorouracil is stable in 5% dextrose injection for at least 16 weeks when stored at 5 degrees C in the two types of containers studied.
研究了氟尿嘧啶在家庭治疗中用于持续输注的塑料容器中制备和储存时的稳定性。氟尿嘧啶用5%葡萄糖注射液稀释。样品在5℃和室温下于聚氯乙烯储药器中储存16周，并在一次性药泵所用的弹性体球囊中于5℃储存。定期通过稳定性指示高效液相色谱（HPLC）法对样品进行检测。在5℃时，没有明显降解。在室温下，氟尿嘧啶浓度逐渐增加，推测是由于水分蒸发。预计在55天内氟尿嘧啶浓度会有10%的变化。在所研究的两种容器中，当在5℃储存时，氟尿嘧啶在5%葡萄糖注射液中至少稳定16周。
