成人眼心反射。格隆溴铵和阿托品的剂量反应研究。
The oculocardiac reflex in adults. A dose response study of glycopyrrolate and atropine.
作者信息
Karhunen U, Cozanitis D A, Brander P
出版信息
Anaesthesia. 1984 Jun;39(6):524-8. doi: 10.1111/j.1365-2044.1984.tb07354.x.
Abstract
Ninety adult patients about to undergo strabismus surgery received glycopyrrolate or atropine intramuscularly. Three doses of each anticholinergic were studied. Cardiac rate and rhythm were recorded during halothane anaesthesia. The oculocardiac reflex, defined as a fall of 20% in heart rate during traction of the extraocular muscle was inhibited in a dose-dependent manner by the drugs studied. The potency ratio of glycopyrrolate to atropine according to the oculocardiac reflex was established as 1:2.
摘要
九十名即将接受斜视手术的成年患者接受了肌肉注射格隆溴铵或阿托品。对每种抗胆碱能药物的三个剂量进行了研究。在氟烷麻醉期间记录心率和心律。眼心反射定义为眼外肌牵引时心率下降20%，所研究的药物以剂量依赖方式抑制该反射。根据眼心反射确定格隆溴铵与阿托品的效价比为1:2。
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