Hunsley J E, Bush G H, Jones C J
Br J Anaesth. 1982 Apr;54(4):459-64. doi: 10.1093/bja/54.4.459.
Glycopyrrolate 5 and 7.5 micrograms kg-1 and atropine 10 and 15 micrograms kg-1 were studied in 80 paediatric patients to assess more fully the dose of glycopyrrolate required for adequate prevention of the oculocardiac reflex. A dose-related improvement in protection from this reflex was seen with both drugs, but neither drug prevented reductions in heart rate in every patient. A nodal rhythm was the most common arrhythmia observed with both drugs. In the doses used, no adverse effects were noted and no further anticholinergic treatment was required during muscle traction. Higher doses may be associated with an increase in side-effects with more pronounced dryness of the mouth and tachycardia and, with atropine, a greater likelihood of the production of the "central anticholinergic syndrome".
在80名儿科患者中研究了5微克/千克和7.5微克/千克的格隆溴铵以及10微克/千克和15微克/千克的阿托品，以更全面地评估充分预防眼心反射所需的格隆溴铵剂量。两种药物均观察到对该反射的保护作用呈剂量相关改善，但两种药物均不能防止每位患者心率降低。结性心律是两种药物观察到的最常见心律失常。在所使用的剂量下，未观察到不良反应，肌肉牵引期间无需进一步抗胆碱能治疗。更高剂量可能与副作用增加有关，口干和心动过速更明显，并且使用阿托品时，产生“中枢抗胆碱能综合征”的可能性更大。
