Sanger D J
Pharmacol Biochem Behav. 1978 Apr;8(4):343-6. doi: 10.1016/0091-3057(78)90068-0.
In the first experiment 4 rats developed schedule-induced water drinking during daily 1 hr sessions of a fixed-time 1 min schedule of food pellet delivery. Injections of a range of doses (0.25, 0.5, 1.0, 2.0 and 4.0 mg/kg) of nicotine hydrogen tartrate were found to produce a dose related attenuation of water intake. The higher doses also reduced the numbers of entries into the food tray in three rats, while the lowest dose consistently facilitated this behavior in the same animals. In a second experiment schedule-induced water drinking developed in 4 other rats under a similar schedule. Substitution of nicotine solution (0.05 and 0.1 mg/ml) for the water reduced volumes of fluid consumed. However, schedule-induced drinking continued at a rate sufficient for the animals to ing-st average doses of the nicotine salt of up to 8.5 mg/kg. It is concluded that schedule-induced drinking can be used successfully as a method of inducing self-administration of nicotine by rats.
在第一个实验中，4只大鼠在每日1小时的固定时间1分钟食物颗粒投递日程中出现了日程诱导性饮水行为。研究发现，注射一系列剂量（0.25、0.5、1.0、2.0和4.0毫克/千克）的酒石酸氢尼古丁会导致饮水摄入量呈剂量相关的减少。较高剂量还减少了3只大鼠进入食物托盘的次数，而最低剂量则持续促进了相同动物的这种行为。在第二个实验中，另外4只大鼠在类似日程下出现了日程诱导性饮水行为。用尼古丁溶液（0.05和0.1毫克/毫升）替代水减少了液体消耗量。然而，日程诱导性饮水仍以足以让动物摄入平均剂量高达8.5毫克/千克尼古丁盐的速率持续。得出的结论是，日程诱导性饮水可成功用作诱导大鼠自我给药尼古丁的一种方法。
