O'Sullivan P A, Matyas T A, King G M
Pharmacol Biochem Behav. 1978 Apr;8(4):357-64. doi: 10.1016/0091-3057(78)90071-0.
The findings of past research using d-tubocurarine chloride as a control procedure in heart rate conditioning have been equivocal. The present experiment compared classical heart rate conditioning under neuromuscular blockade by d-tubocurarine chloride, and a pharmacologically more specific blocker, carbolonium bromide. Both groups were compared to a placebo condition. The results indicated that carbolonium bromide and placebo treated animals acquired deceleratory cardiac conditional responses, but animals treated with d-tubocurarine chloride did not. Unconditional acceleratory responses were found in groups. The findings were discussed in relation to classical conditioning and the psychopharmacology of neuromuscular blockade.
过去在心率条件反射实验中使用氯化筒箭毒碱作为对照程序的研究结果一直存在争议。本实验比较了在氯化筒箭毒碱和药理作用更具特异性的阻断剂溴化卡巴胆碱引起的神经肌肉阻滞情况下的经典心率条件反射。将两组与安慰剂条件进行比较。结果表明，接受溴化卡巴胆碱和安慰剂治疗的动物获得了减速性心脏条件反应，但接受氯化筒箭毒碱治疗的动物没有。在各组中均发现了无条件加速反应。结合经典条件反射和神经肌肉阻滞的精神药理学对这些发现进行了讨论。
