Diwan P V, Sharma P L, Varma Y S
Eur J Pharmacol. 1980 May 2;63(2-3):183-5. doi: 10.1016/0014-2999(80)90442-2.
The effect of sodium nitroprusside (SNP) per se on neuromuscular transmission and its effect on the action of d-tubocurarine (d-Tc) was studied in rabbits and rats. SNP produced a dose-dependent neuromuscular block which was not significantly antagonized by physostigmine. The tetanic response to nerve stimulation was not affected. Pretreatment with SNP significantly increased the intensity and the duration of action of d-Tc. The probable mechanism involved in SNP-induced neuromuscular blockade is discussed.
研究了硝普钠（SNP）本身对神经肌肉传递的影响及其对d -筒箭毒碱（d - Tc）作用的影响，实验对象为家兔和大鼠。SNP产生剂量依赖性神经肌肉阻滞，新斯的明对其无明显拮抗作用。对神经刺激的强直反应不受影响。SNP预处理显著增加了d - Tc作用的强度和持续时间。文中讨论了SNP诱导神经肌肉阻滞的可能机制。
