Kanarek R B, Mayer J
Pharmacol Biochem Behav. 1978 May;8(5):615-7.
Adult male rats fed either ground Purina Laboratory Chow or the same diet adulterated with 0.5% quinine hydrochloride were tested for feeding in response to the administration of 2-deoxy-D-glucose (2-DG). Three doses of 2-DG were used, 250, 500 and 750 mg/kg of body weight. During a six-hr test period, rats given ground Purina Laboratory Chow ate significantly more following intraperitoneal (IP) injections of 250 and 500 mg/kg of 2-DG than following IP injections of physiological saline. Food intake of animals given Purina Chow also increased after administration of 750 mg/kg of 2-DG but intake was not significantly different from that following saline injections. In contrast to rats maintained on the unadulterated diet, rats given quinine-adulterated chow did not increase intake over saline values during the six-hr test period following administration of 250 and 500 mg/kg of 2-DG, and actually decreased intake after injection of 750 mg/kg of 2-DG. Results are discussed with respect to the role of diet palatability in determining food intake in hungry animals.
给成年雄性大鼠喂食普瑞纳实验室标准饲料或添加了0.5%盐酸奎宁的相同饲料，然后检测它们对注射2-脱氧-D-葡萄糖（2-DG）的进食反应。使用了三种剂量的2-DG，分别为250、500和750毫克/千克体重。在为期6小时的测试期间，喂食普瑞纳实验室标准饲料的大鼠腹腔注射250和500毫克/千克2-DG后的进食量显著高于注射生理盐水后的进食量。给予普瑞纳饲料的动物在注射750毫克/千克2-DG后进食量也增加了，但与注射生理盐水后的进食量没有显著差异。与喂食未掺杂饲料的大鼠不同，喂食奎宁掺杂饲料的大鼠在注射250和500毫克/千克2-DG后的6小时测试期间进食量没有超过注射生理盐水后的水平，而在注射750毫克/千克2-DG后进食量实际上减少了。就饮食适口性在饥饿动物进食量决定中的作用对结果进行了讨论。
