Kanarek R B, Marks-Kaufman R, Ruthazer R, Gualtieri L
Pharmacol Biochem Behav. 1983 Jan;18(1):47-50. doi: 10.1016/0091-3057(83)90249-6.
Dietary self-selection was examined following the administration of the glucoprivic agent, 2-deoxy-D-glucose (2-DG), in adult male rats given access to separate sources of the three macronutrients, protein, fat and carbohydrate. All animals received injections (IP) of saline, 250, 500 and 750 mg/kg 2-DG with nutrient intakes measured at 2, 4, 6 and 24 hrs following injections. Animals consumed significantly more carbohydrate at 4, 6 and 24 hrs after injections of 500 and 750 mg/kg 2-DG than after saline injections. In contrast, fat intake was significantly suppressed by all three doses of 2-DG at 2 hr, by 250 and 750 mg/kg 2-DG at 4 and 6 hrs, and by 750 mg/kg 2-DG at 24 hr after injections. Protein intake was significantly decreased by all three doses of 2-DG at 2 hr after injections. As a result of the increase in carbohydrate intake and complimentary decrease in fat intake following 2-DG injections, total caloric intake of animals given the self-selection regime was not modified as a function of drug administration. In comparison, rats given a single nutritionally complete diet (ground Purina Laboratory Chow) consumed significantly more calories following 2-DG administration than following saline injections. The ability of animals to make appropriate modifications in nutrient selection following regulatory challenges is discussed.
在成年雄性大鼠中，给予它们蛋白质、脂肪和碳水化合物这三种宏量营养素的单独来源，然后对其注射糖缺乏剂2-脱氧-D-葡萄糖（2-DG），之后检测其饮食自我选择情况。所有动物均接受腹腔注射生理盐水、250、500和750mg/kg的2-DG，并在注射后2、4、6和24小时测量营养物质摄入量。注射500和750mg/kg 2-DG后4、6和24小时，动物摄入的碳水化合物显著多于注射生理盐水后。相比之下，注射后2小时，所有三种剂量的2-DG均显著抑制脂肪摄入；4和6小时时，250和750mg/kg 2-DG抑制脂肪摄入；24小时时，750mg/kg 2-DG抑制脂肪摄入。注射后2小时，所有三种剂量的2-DG均显著降低蛋白质摄入量。由于注射2-DG后碳水化合物摄入量增加以及脂肪摄入量相应减少，采用自我选择饮食方案的动物的总热量摄入并未因药物给药而改变。相比之下，给予单一营养完全的饮食（普瑞纳实验室磨碎饲料）的大鼠在注射2-DG后比注射生理盐水后消耗的热量显著更多。本文讨论了动物在受到调节挑战后对营养选择进行适当调整的能力。
