镰状细胞贫血贫血危象时的骨髓。
Bone marrow in sickle cell anaemia at time of anaemic crisis.
作者信息
Nkrumah F K, Neequaye J E, Ankra-Badu G
出版信息
Arch Dis Child. 1984 Jun;59(6):561-5. doi: 10.1136/adc.59.6.561.
Samples of bone marrow from 33 Ghanaian children with homozygous sickle cell anaemia who presented with profound anaemia (haemoglobin less than 5 g/dl) were studied. The principal finding was depression of erythropoiesis (aplastic crisis) in 14 children and erythroid hyperplasia in 17. A splenic sequestration crisis was clinically diagnosed in the remaining two children. Stainable iron was absent in the marrow of 14 children and reduced in another five. Megaloblastic changes compatible with folate deficiency were present in 8 children. It is suggested that iron and folate deficiencies may complicate sickle cell anaemia in children living in geographical areas where nutritional deficiencies are prevalent.
对33名患有纯合子镰状细胞贫血且出现严重贫血（血红蛋白低于5g/dl）的加纳儿童的骨髓样本进行了研究。主要发现是14名儿童存在红细胞生成抑制（再生障碍危象），17名儿童存在红系增生。其余两名儿童临床诊断为脾滞留危象。14名儿童的骨髓中无可染色铁，另有5名儿童的可染色铁减少。8名儿童存在与叶酸缺乏相符的巨幼细胞改变。研究表明，在营养缺乏普遍存在的地理区域，铁和叶酸缺乏可能使儿童镰状细胞贫血复杂化。
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