Dalakas M C, Teräväinen H, Engel W K
Arch Neurol. 1984 Jul;41(7):711-4. doi: 10.1001/archneur.1984.04050180033012.
Seven patients with chronic relapsing polyneuropathy and four patients with dysgammaglobulinemic polyneuropathy had tremor during the course of their illness. The tremor was coarse, irregular, and unrelated to proprioception loss, muscle weakness, or fatigue; it appeared to represent disease activity or an early sign of a new relapse. None of these patients had clinical signs of CNS disease or family history of essential tremor. The tremor in all seven patients with relapsing neuropathy and in one of the three treated patients with dysgammaglobulinemia responded to immunosuppressive drugs that controlled the underlying immune mechanism(s) of the disease. In two patients with dysgammaglobulinemic polyneuropathy, the tremor improved with propranolol hydrochloride.
7例慢性复发性多神经病患者和4例免疫球蛋白异常性多神经病患者在病程中出现震颤。震颤粗大、不规则，与本体感觉丧失、肌肉无力或疲劳无关；它似乎代表疾病活动或新复发的早期迹象。这些患者均无中枢神经系统疾病的临床体征或特发性震颤家族史。所有7例复发性神经病患者及3例接受治疗的免疫球蛋白异常血症患者中的1例的震颤对控制疾病潜在免疫机制的免疫抑制药物有反应。在2例免疫球蛋白异常性多神经病患者中，震颤用盐酸普萘洛尔治疗后有所改善。
