小脑学习可区分伴有和不伴有震颤的炎性神经病。
Cerebellar learning distinguishes inflammatory neuropathy with and without tremor.
机构信息
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK.
出版信息
Neurology. 2013 May 14;80(20):1867-73. doi: 10.1212/WNL.0b013e318292a2b8. Epub 2013 Apr 17.
OBJECTIVES
This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls.
METHODS
A prospective data collection study investigating patients with inflammatory neuropathy and tremor, patients with inflammatory neuropathy without tremor, and healthy controls on a test of cerebellar associative learning (eyeblink classical conditioning), a test of sensorimotor integration (short afferent inhibition), and a test of associative plasticity (paired associative stimulation). We also recorded tremor in the arms using accelerometry and surface EMG.
RESULTS
We found impaired responses to eyeblink classical conditioning and paired associative stimulation in patients with neuropathy and tremor compared with neuropathy patients without tremor and healthy controls. Short afferent inhibition was normal in all groups.
CONCLUSIONS
Our data strongly suggest impairment of cerebellar function is linked to the production of tremor in patients with inflammatory neuropathy.
目的
本研究旨在探究炎性神经病伴震颤患者与不伴震颤的炎性神经病患者及健康对照者相比，小脑是否存在功能障碍，感觉运动皮层之间是否存在相互作用。
方法
前瞻性数据收集研究，对炎性神经病伴震颤患者、炎性神经病不伴震颤患者和健康对照者进行小脑联合学习（眨眼条件反射）、感觉运动整合（短传入抑制）和联合可塑性（成对联合刺激）测试。我们还使用加速度计和表面肌电图记录手臂震颤。
结果
与不伴震颤的炎性神经病患者和健康对照组相比，伴震颤的炎性神经病患者的眨眼条件反射和成对联合刺激反应受损。所有组的短传入抑制均正常。
结论
我们的数据强烈表明，炎性神经病患者震颤的产生与小脑功能障碍有关。
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