Moriguchi R, Fujimoto Y, Izawa H
Avian Dis. 1984 Apr-Jun;28(2):331-42.
The present study confirmed that Marek's disease (MD)-associated nuclear-inclusion (NI) formation in the feather-follicle epithelium (FFE) is related to mortality from MD; it also presented useful data on the epidemiology of MD in HVT-vaccinated field chickens. Incidence of NI formation in the FFE of chickens on six rearing farms varied greatly by age and flock, but most of the field flocks showed biphasic peaks of incidence of NI in chickens consisting of a small peak at an early age (usually at 2-4 weeks of age) and a large peak between 13 and 16 weeks of age. MD tended to occur in chickens over 20 weeks old, and almost all MD-affected chickens showed NI formation persistently in the FFE, usually between 13 and 20 weeks of age. Chickens that were healthy at the end of observation showed either transient NI formation, usually between 13 and 16 weeks of age, or no detectable NI formation. Incidence of NI formation in the FFE of chickens at 19-20 weeks of age was related to mortality from MD: chickens with NI formation had a MD mortality rate of 66.7%, whereas chickens without NI formation had MD mortality of only 0.8%.
本研究证实，羽囊上皮（FFE）中与马立克氏病（MD）相关的核内包涵体（NI）形成与MD导致的死亡率有关；它还提供了关于接种HVT的商品鸡群中MD流行病学的有用数据。六个饲养场鸡的FFE中NI形成的发生率因年龄和鸡群不同而有很大差异，但大多数商品鸡群中鸡的NI发生率呈双相峰值，包括早期（通常在2 - 4周龄）的一个小峰值和13至16周龄之间的一个大峰值。MD往往发生在20周龄以上的鸡中，几乎所有受MD影响的鸡在FFE中都持续出现NI形成，通常在13至20周龄之间。观察结束时健康的鸡要么在13至16周龄之间出现短暂的NI形成，要么未检测到NI形成。19 - 20周龄鸡的FFE中NI形成的发生率与MD导致的死亡率有关：有NI形成的鸡的MD死亡率为66.7%，而没有NI形成的鸡的MD死亡率仅为0.8%。
