Moriguchi R, Fujimoto Y, Izawa H
Avian Dis. 1982 Apr-Jun;26(2):375-88.
Observations of the feather pulp from chickens inoculated with Marek's disease (MD) virus revealed diverse lesions similar to those in the peripheral nerves of chickens infected with MD. These lesions were categorized as follows: R1-type lesions = from minimal perivascular to diffuse infiltration of small lymphocytes mixed with a few medium lymphocytes or blast cells; R2-type lesion = edema and cellular infiltration consisting of plasma cells and small lymphocytes; and T-type lesion = tumorous proliferation of lymphoid cells predominantly composed of medium lymphocytes or blast cells. Chronological observations of the feather pulp biopsies taken at 2-week intervals from individual chickens revealed the lesion progression R1-type leads to T-type, or R1-type leads to R2-type. The former progression was usually seen in birds showing evidence of both persistent nuclear-inclusion (NI) formation in the feather-follicle epithelium (FFE) and development of lymphoid tumors in the viscera. The latter progression was seen exclusively in chickens that showed transient NI formation in the FFE, regardless of the incidence of MD.
对接种马立克氏病（MD）病毒的鸡的羽髓观察发现，其病变多样，与感染MD的鸡外周神经中的病变相似。这些病变分类如下：R1型病变 = 从轻微血管周围到小淋巴细胞弥漫性浸润，混有少量中等淋巴细胞或母细胞；R2型病变 = 水肿以及由浆细胞和小淋巴细胞组成的细胞浸润；T型病变 = 主要由中等淋巴细胞或母细胞组成的淋巴样细胞肿瘤性增殖。对每隔2周从个体鸡采集的羽髓活检进行的时间顺序观察显示，病变进展为R1型导致T型，或R1型导致R2型。前一种进展通常见于在羽囊上皮（FFE）中显示持续核内包涵体（NI）形成证据且内脏出现淋巴样肿瘤的鸡。后一种进展仅见于在FFE中显示短暂NI形成的鸡，无论MD的发病率如何。
