苯巴比妥对大鼠睾丸中谷胱甘肽S-转移酶D的选择性诱导作用。
Selective induction of glutathione S-transferase D in rat testis by phenobarbital.
作者信息
Sheehan D, Ryle C M, Mantle T J
出版信息
Biochem J. 1984 Apr 15;219(2):687-8. doi: 10.1042/bj2190687.
Abstract
Testis cytosol is shown to contain the Yb2Yb2 -homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A ( Yb1Yb1 ) and C ( Yb1Yb2 ). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.
摘要
睾丸胞质溶胶中除了先前描述的谷胱甘肽S-转移酶A（Yb1Yb1）和C（Yb1Yb2）外，还含有Yb2Yb2-同型二聚体谷胱甘肽S-转移酶D。用苯巴比妥处理大鼠可诱导睾丸中谷胱甘肽S-转移酶D的水平升高，而谷胱甘肽S-转移酶A和C的活性没有增加。这一结果表明睾丸中Yb2亚基有特异性诱导，这与大鼠肝脏的情况相反，在大鼠肝脏中苯巴比妥特异性诱导Yb1亚基。
相似文献
1
Selective induction of glutathione S-transferase D in rat testis by phenobarbital.苯巴比妥对大鼠睾丸中谷胱甘肽S-转移酶D的选择性诱导作用。
Biochem J. 1984 Apr 15;219(2):687-8. doi: 10.1042/bj2190687.
2
Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro.谷胱甘肽S-转移酶P、S和N的纯化与特性分析。从大鼠肝脏中分离出Yb1 Yn蛋白，其存在是通过体外亚基杂交预测的。
Biochem J. 1984 Dec 15;224(3):839-52. doi: 10.1042/bj2240839.
3
Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix.喂食含抗癌抗氧化剂丁基羟基茴香醚饮食的小鼠肝脏谷胱甘肽S-转移酶。通过谷胱甘肽-琼脂糖亲和基质梯度洗脱分离小鼠谷胱甘肽S-转移酶异二聚体。
Biochem J. 1991 Jul 15;277 ( Pt 2)(Pt 2):501-12. doi: 10.1042/bj2770501.
4
Effect of phenobarbital on the induction of glutathione S-transferases in rat testis.苯巴比妥对大鼠睾丸中谷胱甘肽S-转移酶诱导作用的影响。
Reprod Biomed Online. 2004 Jan;8(1):68-74. doi: 10.1016/s1472-6483(10)60499-3.
5
6
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene.六氯苯和异硫氰酸苄酯对大鼠肝脏谷胱甘肽S-转移酶同工酶的差异诱导作用。与苯巴比妥和3-甲基胆蒽诱导作用的比较。
Biochem Pharmacol. 1988 Mar 15;37(6):1077-82. doi: 10.1016/0006-2952(88)90513-8.
7
Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney.苯巴比妥、3-甲基胆蒽和乙氧喹对大鼠肝脏和肾脏中谷胱甘肽S-转移酶亚基的差异诱导作用。
Biochim Biophys Acta. 1993 Oct 3;1158(2):175-80. doi: 10.1016/0304-4165(93)90011-v.
8
9
Drug induction and sex differences of renal glutathione S-transferases in the rat.大鼠肾谷胱甘肽S-转移酶的药物诱导及性别差异
Biochem J. 1975 Aug;150(2):259-62. doi: 10.1042/bj1500259.
10
Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.化学保护剂对黄曲霉毒素B1代谢醛还原酶和谷胱甘肽S-转移酶的调控
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):117-24. doi: 10.1042/bj3000117.
引用本文的文献
1
Effects of dietary broccoli on rat testicular xenobiotic metabolizing enzymes.膳食西兰花对大鼠睾丸外源性物质代谢酶的影响。
Eur J Drug Metab Pharmacokinet. 1999 Oct-Dec;24(4):353-9. doi: 10.1007/BF03190044.
2
Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro.谷胱甘肽S-转移酶P、S和N的纯化与特性分析。从大鼠肝脏中分离出Yb1 Yn蛋白，其存在是通过体外亚基杂交预测的。
Biochem J. 1984 Dec 15;224(3):839-52. doi: 10.1042/bj2240839.
3
A subclass of glutathione S-transferases as intracellular high-capacity and high-affinity steroid-binding proteins.谷胱甘肽S-转移酶的一个亚类作为细胞内高容量和高亲和力的类固醇结合蛋白。
Biochem J. 1986 May 1;235(3):763-8. doi: 10.1042/bj2350763.
本文引用的文献
1
Tissue distribution and subunit structures of the multiple forms of glutathione S-transferase in the rat.大鼠体内谷胱甘肽S-转移酶多种形式的组织分布及亚基结构
Biochem J. 1981 Jan 1;193(1):367-70. doi: 10.1042/bj1930367.
2
3
Evidence for two forms of ligandin (YaYa dimers of glutathione S-transferase) in rat liver and kidney.大鼠肝脏和肾脏中两种形式的配体蛋白（谷胱甘肽S-转移酶的YaYa二聚体）的证据。
Biochem J. 1984 Mar 15;218(3):893-7. doi: 10.1042/bj2180893.
4
Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes.大鼠肝脏谷胱甘肽S-转移酶。对含基本YbYb的酶的结构研究。
Biochem J. 1983 Sep 1;213(3):625-33. doi: 10.1042/bj2130625.
5
Subunit composition of rat liver glutathione S-transferases.大鼠肝脏谷胱甘肽S-转移酶的亚基组成
Biochem Biophys Res Commun. 1982 Sep 30;108(2):461-7. doi: 10.1016/0006-291x(82)90851-8.
6
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.谷胱甘肽S-转移酶。硫醚氨酸形成过程中的首个酶促步骤。
J Biol Chem. 1974 Nov 25;249(22):7130-9.
7
Identification of two lithocholic acid-binding proteins. Separation of ligandin from glutathione S-transferase B.两种石胆酸结合蛋白的鉴定。将配体蛋白与谷胱甘肽S-转移酶B分离。
Biochem J. 1979 Sep 1;181(3):699-708. doi: 10.1042/bj1810699.
Zotero 插件