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苯巴比妥对大鼠睾丸中谷胱甘肽S-转移酶D的选择性诱导作用。

Selective induction of glutathione S-transferase D in rat testis by phenobarbital.

作者信息

Sheehan D, Ryle C M, Mantle T J

出版信息

Biochem J. 1984 Apr 15;219(2):687-8. doi: 10.1042/bj2190687.

DOI:10.1042/bj2190687
PMID:6743236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153528/
Abstract

Testis cytosol is shown to contain the Yb2Yb2 -homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A ( Yb1Yb1 ) and C ( Yb1Yb2 ). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.

摘要

睾丸胞质溶胶中除了先前描述的谷胱甘肽S-转移酶A（Yb1Yb1）和C（Yb1Yb2）外，还含有Yb2Yb2-同型二聚体谷胱甘肽S-转移酶D。用苯巴比妥处理大鼠可诱导睾丸中谷胱甘肽S-转移酶D的水平升高，而谷胱甘肽S-转移酶A和C的活性没有增加。这一结果表明睾丸中Yb2亚基有特异性诱导，这与大鼠肝脏的情况相反，在大鼠肝脏中苯巴比妥特异性诱导Yb1亚基。

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Selective induction of glutathione S-transferase D in rat testis by phenobarbital.苯巴比妥对大鼠睾丸中谷胱甘肽S-转移酶D的选择性诱导作用。
Biochem J. 1984 Apr 15;219(2):687-8. doi: 10.1042/bj2190687.
2
Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro.谷胱甘肽S-转移酶P、S和N的纯化与特性分析。从大鼠肝脏中分离出Yb1 Yn蛋白，其存在是通过体外亚基杂交预测的。
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[Isolation and comparative analysis of multiple isoenzymes of glutathione-S-transferase from the liver of intact rats and rats administered phenobarbital, 3-methylcholanthrene and butylhydroxytoluene].[从完整大鼠以及给予苯巴比妥、3-甲基胆蒽和丁基羟基甲苯的大鼠肝脏中分离并比较谷胱甘肽-S-转移酶的多种同工酶]
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Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.化学保护剂对黄曲霉毒素B1代谢醛还原酶和谷胱甘肽S-转移酶的调控
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引用本文的文献

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Effects of dietary broccoli on rat testicular xenobiotic metabolizing enzymes.膳食西兰花对大鼠睾丸外源性物质代谢酶的影响。
Eur J Drug Metab Pharmacokinet. 1999 Oct-Dec;24(4):353-9. doi: 10.1007/BF03190044.
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Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro.谷胱甘肽S-转移酶P、S和N的纯化与特性分析。从大鼠肝脏中分离出Yb1 Yn蛋白，其存在是通过体外亚基杂交预测的。
Biochem J. 1984 Dec 15;224(3):839-52. doi: 10.1042/bj2240839.
3
A subclass of glutathione S-transferases as intracellular high-capacity and high-affinity steroid-binding proteins.谷胱甘肽S-转移酶的一个亚类作为细胞内高容量和高亲和力的类固醇结合蛋白。
Biochem J. 1986 May 1;235(3):763-8. doi: 10.1042/bj2350763.

本文引用的文献

1
Tissue distribution and subunit structures of the multiple forms of glutathione S-transferase in the rat.大鼠体内谷胱甘肽S-转移酶多种形式的组织分布及亚基结构
Biochem J. 1981 Jan 1;193(1):367-70. doi: 10.1042/bj1930367.
2
Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol.四种具有不同催化特异性的蛋白质亚基的二元组合解释了大鼠肝细胞溶质中六种基本谷胱甘肽S-转移酶之间的关系。
J Biol Chem. 1982 Sep 10;257(17):9909-12.
3
Evidence for two forms of ligandin (YaYa dimers of glutathione S-transferase) in rat liver and kidney.大鼠肝脏和肾脏中两种形式的配体蛋白（谷胱甘肽S-转移酶的YaYa二聚体）的证据。
Biochem J. 1984 Mar 15;218(3):893-7. doi: 10.1042/bj2180893.
4
Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes.大鼠肝脏谷胱甘肽S-转移酶。对含基本YbYb的酶的结构研究。
Biochem J. 1983 Sep 1;213(3):625-33. doi: 10.1042/bj2130625.
5
Subunit composition of rat liver glutathione S-transferases.大鼠肝脏谷胱甘肽S-转移酶的亚基组成
Biochem Biophys Res Commun. 1982 Sep 30;108(2):461-7. doi: 10.1016/0006-291x(82)90851-8.
6
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.谷胱甘肽S-转移酶。硫醚氨酸形成过程中的首个酶促步骤。
J Biol Chem. 1974 Nov 25;249(22):7130-9.
7
Identification of two lithocholic acid-binding proteins. Separation of ligandin from glutathione S-transferase B.两种石胆酸结合蛋白的鉴定。将配体蛋白与谷胱甘肽S-转移酶B分离。
Biochem J. 1979 Sep 1;181(3):699-708. doi: 10.1042/bj1810699.