三苯乙醇对恒河猴胆固醇吸收的影响。
Effect of triparanol on cholesterol absorption in rhesus monkeys.
作者信息
Bhattacharyya A K, Eggen D A
出版信息
Atherosclerosis. 1984 May-Jun;51(2-3):293-8. doi: 10.1016/0021-9150(84)90176-x.
The drug, triparanol, a known inhibitor of cholesterol biosynthesis, was found to interfere with absorption of cholesterol in rhesus monkeys. The percent luminal cholesterol absorbed decreased by 13 and 21%, respectively, in the high- and low-responding monkeys when the drug was fed along with the low-cholesterol, low-plant sterol diet. When the diet contained large amounts of plant sterols, feeding of the drug also reduced the percent cholesterol absorption by the same order of magnitude. The results showed that triparanol decreased the absorption of endogenous cholesterol in rhesus monkeys. The effect of the drug on cholesterol absorption was independent of that of plant sterols. The mechanism(s) of the observed inhibitory effect of triparanol on cholesterol absorption is not clearly understood.
药物曲帕拉醇是一种已知的胆固醇生物合成抑制剂，研究发现它会干扰恒河猴体内胆固醇的吸收。当该药物与低胆固醇、低植物甾醇饮食一起投喂时，高反应性和低反应性恒河猴的肠腔胆固醇吸收百分比分别下降了13%和21%。当饮食中含有大量植物甾醇时，投喂该药物也会使胆固醇吸收百分比降低相同数量级。结果表明，曲帕拉醇降低了恒河猴体内内源性胆固醇的吸收。该药物对胆固醇吸收的影响与植物甾醇无关。目前尚不清楚曲帕拉醇对胆固醇吸收产生抑制作用的机制。
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