Bhattacharyya A K, Eggen D A
Atherosclerosis. 1984 Dec;53(3):225-32. doi: 10.1016/0021-9150(84)90123-0.
The effects of feeding diets with high or low amounts of cholesterol and with low or high levels of mixed plant sterols (sitosterol: campesterol: stigmasterol, 60:35:5) on the daily fecal excretion of acidic steroids were studied in rhesus monkeys. During periods of low dietary plant sterol, total fecal acidic steroid excretion was 43% lower (P less than 0.01) during low dietary cholesterol than during high dietary cholesterol. During periods of high dietary plant sterols the fecal acidic steroid excretion was 113% higher (P less than 0.01) with low dietary cholesterol than with high dietary cholesterol. Addition of mixed plant sterols to the low-cholesterol diet produced nearly a 2-fold increase (P less than 0.005) whereas, such an addition to the high cholesterol diet produced a significant decrease by about 53% (P less than 0.025) in the total fecal acidic steroid excretion. The results suggest that the effect of cholesterol feeding on fecal acidic steroid excretion depends on the level of plant sterols in the diet. This interaction of the effects of cholesterol and plant sterols on the fecal acidic steroid excretion is probably related to the inhibitory effect of plant sterols on cholesterol absorption.
在恒河猴中研究了喂食高胆固醇或低胆固醇以及低混合植物甾醇水平或高混合植物甾醇水平（谷甾醇：菜油甾醇：豆甾醇，60:35:5）的饮食对酸性类固醇每日粪便排泄量的影响。在低膳食植物甾醇期间，低膳食胆固醇时的粪便酸性类固醇总排泄量比高膳食胆固醇时低43%（P<0.01）。在高膳食植物甾醇期间，低膳食胆固醇时的粪便酸性类固醇排泄量比高膳食胆固醇时高113%（P<0.01）。在低胆固醇饮食中添加混合植物甾醇使粪便酸性类固醇总排泄量增加近2倍（P<0.005），而在高胆固醇饮食中添加混合植物甾醇则使粪便酸性类固醇总排泄量显著降低约53%（P<0.025）。结果表明，喂食胆固醇对粪便酸性类固醇排泄的影响取决于饮食中植物甾醇的水平。胆固醇和植物甾醇对粪便酸性类固醇排泄的这种相互作用可能与植物甾醇对胆固醇吸收的抑制作用有关。
