Hassan A S, Srivastava L S, Yunker R L, Subbiah M T
Atherosclerosis. 1984 May-Jun;51(2-3):327-33. doi: 10.1016/0021-9150(84)90180-1.
Feeding cholestyramine to weaned rats increased the bile acid pool and activity of cholesterol 7 alpha-hydroxylase as expected. Following adrenalectomy, cholestyramine still increased the activity of cholesterol 7 alpha-hydroxylase but the magnitude of increase was lower (P less than 0.01) than noted in intact rats. Surprisingly, cholestyramine feeding to both intact and adrenalectomized rats increased plasma levels of corticosterone.
如预期的那样，给断奶大鼠喂食消胆胺可增加胆汁酸池和胆固醇7α-羟化酶的活性。肾上腺切除术后，消胆胺仍可增加胆固醇7α-羟化酶的活性，但增加幅度低于完整大鼠（P<0.01）。令人惊讶的是，给完整大鼠和肾上腺切除大鼠喂食消胆胺均可增加血浆皮质酮水平。
