Hassan A S, Gallon L S, Zimmer L A, Balistreri W F, Subbiah M T
Steroids. 1981 Oct;38(4):477-84. doi: 10.1016/0039-128x(81)90081-7.
Cholesterol catabolism to bile acids was stimulated in neonatal guinea pigs by feeding 1.11% cholestyramine (CT)-containing diet for 8 weeks. The animals were then switched to standard laboratory diet for an additional 4 weeks. At the end of the laboratory diet period: a) CT-pre-treated guinea pigs continued to excrete significantly higher (p less than 0.05) amounts of bile acids, b) the activity of hepatic 7 alpha-hydroxylase was significantly elevated (p less than 0.01) in CT-pre-treated animals, and c) isolated hepatocytes from CT-pre-treated guinea pigs secreted significantly higher (p less than 0.05) amounts of bile acid when compared to controls during a 4-hour incubation. These data provide biochemical support for our contention that stimulation of cholesterol catabolism during neonatal life can have effects that persist into adult life.
通过给新生豚鼠喂食含1.11%消胆胺（CT）的饮食8周，刺激了胆固醇向胆汁酸的分解代谢。然后将这些动物再换成标准实验室饮食4周。在实验室饮食期结束时：a）经CT预处理的豚鼠继续排泄显著更多（p<0.05）的胆汁酸；b）在经CT预处理的动物中，肝脏7α-羟化酶的活性显著升高（p<0.01）；c）与对照组相比，在4小时的孵育过程中，从经CT预处理的豚鼠分离出的肝细胞分泌的胆汁酸显著更多（p<0.05）。这些数据为我们的论点提供了生化支持，即新生儿期胆固醇分解代谢的刺激作用可持续到成年期。
