Poelman M C, Leveque J L, Le Gall F
Br J Dermatol. 1984 Jul;111 Suppl 27:158-62. doi: 10.1111/j.1365-2133.1984.tb15596.x.
In order to quantify the intensity of skin blanching and thus predict the bioavailability of topical corticoids, a physical device allowing the measurement of light reflected from skin without any contact between the probe and the skin was used (Leveque et al., 1984). Three series of experiments were carried out: firstly, to assess the vasoconstrictor potency of four corticoids; secondly, to show the influence of the vehicle on the bioavailability of the same drug under various galenic forms, such as fatty ointments or water in oil (W/O) and oil in water (O/W) creams; thirdly, to determine the reservoir effects, if any, of some of these formulations. The results confirm previous findings about the potency of hydrocortisone acetate, triamcinolone 17-acetonide, betamethasone 17-valerate, diflucortolone valerate and clobetasol 17-propionate.
为了量化皮肤变白的强度从而预测局部用皮质类固醇的生物利用度，使用了一种物理装置，该装置能够在探头与皮肤无任何接触的情况下测量皮肤反射的光（勒韦克等人，1984年）。进行了三组实验：第一，评估四种皮质类固醇的血管收缩效力；第二，展示载体对同一药物在不同剂型（如脂肪软膏、油包水（W/O）和水包油（O/W）乳膏）下生物利用度的影响；第三，确定其中一些制剂是否存在储库效应。结果证实了先前关于醋酸氢化可的松、曲安奈德17 - 丙酮化物、倍他米松17 - 戊酸酯、二氟可龙戊酸酯和丙酸氯倍他索效力的研究结果。
