Lévêque J L, Poelman M C, Legall F, de Rigal J
Dermatologica. 1985;170(1):12-6. doi: 10.1159/000249488.
By modifying the blood supply in the upper part of the dermis, the colour of the skin is changed by any material in contact with it. This is a great difficulty when we want to measure the colour intensity in erythema or blanching. To avoid this problem, we designed and built a device which measures the skin reflectance value without any contact with the skin. The use of this device on man to study the skin blanching after application of dermocorticoids allows us to determine the more potent drug among a series (clobetasol propionate) and, for a given drug (betamethasone), the more efficient preparation (oil-in-water emulsion). The study of the effect of increasing irradiation doses of ultraviolet light show that the sensitivity of the device is equivalent to that of the clinical assessment and that the relationship between the irradiation dose and the skin reflectance is sigmoidal.
通过改变真皮上部的血液供应，与皮肤接触的任何物质都会改变皮肤的颜色。当我们想要测量红斑或皮肤变白中的颜色强度时，这是一个很大的困难。为了避免这个问题，我们设计并制造了一种无需与皮肤接触就能测量皮肤反射率值的设备。在人体上使用该设备研究应用皮质类固醇后皮肤变白的情况，使我们能够在一系列药物（丙酸氯倍他索）中确定效力更强的药物，对于给定的药物（倍他米松），还能确定更有效的制剂（水包油乳剂）。对增加紫外线照射剂量效果的研究表明，该设备的灵敏度与临床评估相当，并且照射剂量与皮肤反射率之间的关系呈S形。
