Nolen W A, Börger J
Pharmakopsychiatr Neuropsychopharmakol. 1978 Jul;11(4):199-204. doi: 10.1055/s-0028-1094579.
In a study in 97 patients on the occurrence of disturbances of liver functions by use of long acting neuroleptic drugs (fluphenazine decanoate, flupenthixol decanoate and fluspirilene) no indications were found that these agents, even in relatively high dosages, are hepatotoxic. Furthermore, in 40% of the patients slight disturbances were found, which nevertheless, were not specific in nature, and mostly concerned the turbidity tests. In spite of these findings a regular control (for instances, once a year) of the liver functions in patients with long acting neuroleptic drugs seems to be called for.
在一项针对97例使用长效抗精神病药物（癸酸氟奋乃静、癸酸氟哌噻吨和氟司必林）患者肝功能紊乱发生情况的研究中，未发现这些药物即使在相对高剂量时具有肝毒性的迹象。此外，40%的患者出现了轻微紊乱，但这些紊乱本质上并不具有特异性，主要涉及浊度测试。尽管有这些发现，对于使用长效抗精神病药物的患者，似乎仍需要定期（例如每年一次）检查肝功能。
