O'Grady J G, Harding B, Egan E L, Murphy B, O'Gorman T A, McCarthy C F
Br J Haematol. 1984 Jul;57(3):441-6. doi: 10.1111/j.1365-2141.1984.tb02918.x.
'Pitted' erythrocyte counts are widely used in the quantitative assessment of functional hyposplenism and in the prediction of recurrence of splenic function in splenectomized subjects. Both of these functions require counts from electively splenectomized controls for comparison. The 'pitted' erythrocyte counts in patients splenectomized for congenital spherocytosis are lower than those found in subjects whose spleens were removed electively for other reasons. This appears to be due to the specific membrane defect which impairs the formation of the vacuoles which are responsible for the appearance of 'pitted' erythrocytes under the interference-phase microscope.
“有凹陷”红细胞计数广泛应用于功能性脾功能减退的定量评估以及脾切除患者脾功能复发的预测。这两项功能都需要择期脾切除对照组的计数进行比较。因先天性球形红细胞增多症而脾切除的患者的“有凹陷”红细胞计数低于因其他原因择期切除脾脏的受试者。这似乎是由于特定的膜缺陷，该缺陷会损害空泡的形成，而空泡是在干涉相显微镜下导致“有凹陷”红细胞出现的原因。
