Lopez A F, Strath M, Sanderson C J
Br J Haematol. 1984 Jul;57(3):489-94. doi: 10.1111/j.1365-2141.1984.tb02923.x.
A panel of hybridomas secreting monoclonal antibodies (mAb) reacting with antigens on mouse eosinophils and neutrophils has been selected. It is shown that four mAb bind preferentially to eosinophils, recognizing antigens expressed between 5 and 25 times more densely on these cells than on neutrophils. One mAb reacts preferentially with neutrophils, binding an antigen about 12 times more common on these cells than on eosinophils. Four mAb are shown to react with both eosinophils and neutrophils, and also macrophages. These mAb confirm the presence of different differentiation antigens on both eosinophils and neutrophils, and show that the myeloid series express antigens not expressed on lymphocytes.
已筛选出一组分泌与小鼠嗜酸性粒细胞和中性粒细胞上抗原发生反应的单克隆抗体（mAb）的杂交瘤。结果表明，四种mAb优先结合嗜酸性粒细胞，识别这些细胞上表达的抗原密度比中性粒细胞高5至25倍。一种mAb优先与中性粒细胞反应，结合的抗原在这些细胞上比在嗜酸性粒细胞上常见约12倍。四种mAb被证明可与嗜酸性粒细胞、中性粒细胞以及巨噬细胞发生反应。这些mAb证实了嗜酸性粒细胞和中性粒细胞上存在不同的分化抗原，并表明髓系表达淋巴细胞上未表达的抗原。
