Woodman C B, Jordan J A, Wade-Evans T
Br J Obstet Gynaecol. 1984 Jul;91(7):707-11. doi: 10.1111/j.1471-0528.1984.tb04835.x.
Twenty-three patients with vaginal intraepithelial neoplasia (VaIN) presented between 6 months and 13 years after hysterectomy for cervical intraepithelial neoplasia. All were discovered by cytological follow-up, were colposcopically assessed and diagnosis confirmed by histological examination before treatment. The CO2 laser was used as the initial treatment in 14, but only six remain free of disease after mean follow-up of 30 months. The reasons for the disappointing results with this form of therapy are discussed and it is suggested that its use may be inappropriate in the management of VaIN following hysterectomy as atypical epithelium may frequently be inaccessible as a result of being sequestered above the vault suture line or hidden in the recesses of the angles of the vaginal vault.
23例阴道上皮内瘤变（VaIN）患者在因宫颈上皮内瘤变行子宫切除术后6个月至13年出现。所有患者均通过细胞学随访发现，经阴道镜评估，并在治疗前通过组织学检查确诊。14例患者最初采用二氧化碳激光治疗，但平均随访30个月后，只有6例无疾病复发。文中讨论了这种治疗方式效果不佳的原因，并指出在子宫切除术后VaIN的管理中使用该方法可能不合适，因为非典型上皮可能经常因被隔离在穹窿缝线以上或隐藏在阴道穹窿角的凹陷处而难以触及。
