Gibson J M, Fielder A R, Garner A, Millac P
Br J Ophthalmol. 1984 Aug;68(8):553-60. doi: 10.1136/bjo.68.8.553.
We report a case of perhexilene maleate (PEXID) toxicity in which the presenting feature was loss of vision secondary to chronic papilloedema. Vortex keratopathy similar to that seen in amiodarone keratopathy was present, and corneal and conjunctival biopsy findings are presented. To our knowledge this is the first case report of a keratopathy occurring in perhexilene toxicity. After withdrawal of the drug the papilloedema and keratopathy subsided, but some visual deficit remains. The properties of perhexilene maleate and other amphiphilic drugs are described, and the possible aetiology of vortex keratopathy is discussed.
我们报告一例马来酸哌克昔林（PEXID）中毒病例，其主要表现为慢性视乳头水肿继发视力丧失。存在与胺碘酮角膜病变相似的涡状角膜病变，并展示了角膜和结膜活检结果。据我们所知，这是首例关于哌克昔林毒性所致角膜病变的病例报告。停药后，视乳头水肿和角膜病变消退，但仍存在一些视力缺陷。描述了马来酸哌克昔林及其他两亲性药物的特性，并讨论了涡状角膜病变可能的病因。
