Fairweather-Tait S J, Payne V, Williams C M
Br J Nutr. 1984 Jul;52(1):79-86. doi: 10.1079/bjn19840073.
Female Wistar rats were given an adequate-zinc (60 micrograms/g) or low-Zn (7 micrograms/g) diet for a minimum of 2 weeks and then mated. They were then either continued on the same diets (+Zn -Fe or -Zn -Fe) or given similar diets supplemented with four times the normal level of iron (+Zn +Fe or -Zn + Fe). The day before parturition they were killed and the fetuses removed and analysed. There were no differences in numbers of fetuses or the number of resorption sites. In the absence of Fe supplementation, the mean fetal wet weight was significantly less (P less than 0.05) in the low-Zn group but there was no effect of Zn in the two Fe-supplemented groups. The addition of Fe significantly decreased (P less than 0.05) the mean fetal wet weight in the adequate-Zn groups but had no effect in the low-Zn groups. There were no differences in fetal dry weight, fat, protein or DNA content. Both Fe-supplemented groups produced fetuses of higher Fe concentration (P less than 0.01), and mothers with higher bone Fe-concentration (P less than 0.01) compared with the non-supplemented groups. The low-Zn groups produced fetuses of lower Zn concentration (P less than 0.001) than the adequate-Zn groups but there was no effect on maternal bone Zn concentration. It was concluded that Fe-supplements did not adversely affect fetal growth from mothers given a low-Zn diet, but the addition of Zn to the unsupplemented diet increased fetal wet weight.(ABSTRACT TRUNCATED AT 250 WORDS)
将雌性Wistar大鼠给予充足锌（60微克/克）或低锌（7微克/克）饮食至少2周，然后进行交配。之后，它们要么继续食用相同的饮食（+锌 -铁或 -锌 -铁），要么给予补充了四倍正常铁水平的类似饮食（+锌 +铁或 -锌 +铁）。在分娩前一天将它们处死，取出胎儿并进行分析。胎儿数量或吸收部位数量没有差异。在不补充铁的情况下，低锌组的平均胎儿湿重显著更低（P小于0.05），但在两个补充铁的组中锌没有影响。补充铁显著降低了（P小于0.05）充足锌组的平均胎儿湿重，但在低锌组中没有影响。胎儿干重、脂肪、蛋白质或DNA含量没有差异。与未补充组相比，两个补充铁的组产生的胎儿铁浓度更高（P小于0.01），母亲的骨铁浓度也更高（P小于0.01）。低锌组产生的胎儿锌浓度低于充足锌组（P小于0.001），但对母体骨锌浓度没有影响。得出的结论是，补充铁对低锌饮食母亲的胎儿生长没有不利影响，但在未补充饮食中添加锌会增加胎儿湿重。（摘要截短至250字）
