Grinde B
Biochim Biophys Acta. 1984 Jul 30;800(2):140-4. doi: 10.1016/0304-4165(84)90052-7.
Benzyl alcohol caused a rather complete and selective inhibition of the methylamine sensitive (i.e., the putative lysosomal) pathway of protein degradation in isolated rat hepatocytes. The effect was found to be entirely reversible within 30 min of removing the agent. A morphometric examination of electron micrographs revealed that the inhibition of lysosomal protein degradation coincided with a block in the formation of autophagic vacuoles. The number of acidic vacuoles (i.e., vacuoles induced to swell by adding methylamine) was not drastically reduced.
苯甲醇对离体大鼠肝细胞中蛋白质降解的甲胺敏感（即假定的溶酶体）途径产生了相当完全且选择性的抑制作用。发现该作用在去除该试剂后30分钟内完全可逆。对电子显微镜照片的形态计量学检查显示，溶酶体蛋白质降解的抑制与自噬泡形成的阻滞同时发生。酸性液泡（即通过添加甲胺诱导肿胀的液泡）的数量并未大幅减少。
