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精神分裂症及其他精神疾病患者的神经心理损害及相关智力功能

Neuropsychological impairment and associated intellectual functions in schizophrenic and other psychiatric patients.

作者信息

Donnelly E F

出版信息

Biol Psychiatry. 1984 Jun;19(6):815-24.

PMID:6743719
Abstract

As a routine admission procedure of an ongoing research program, the Halstead-Reitan Battery (HRB) and the Wechsler Adult Intelligence Scale (WAIS) were completed by 37 chronic schizophrenic patients, 3 patients with major affective disorders, and 2 with atypical psychoses. These admission data provided a basis for a retrospective investigation into the possibility of a relationship between impairment on the HRB and IQ. It was found that greater impairment on the HRB was associated with lower full-scale IQ (FSIQ) scores (r = -0.78, p less than .001). When the sample was separated into impaired and normal groups based on performance on the HRB, the coefficients of two discriminant functions, i.e., Verbal IQ and Picture Arrangement, classified the two groups with 100% accuracy. Cross-validation of the stepwise discriminant function analysis, using the jackknife procedure, resulted in a 98% hit rate. The results of the present study together with those of two other recent studies suggest that intellectual functions are critical interactive variables for interpreting the performance of chronic schizophrenic and other psychiatric groups on the HRB. Cautions to be observed in interpreting impaired and normal functioning in the context of intellectual functions are discussed.

摘要

作为一项正在进行的研究项目的常规入院程序,37名慢性精神分裂症患者、3名重度情感障碍患者和2名非典型精神病患者完成了霍尔斯特德-赖坦成套神经心理测验(HRB)和韦氏成人智力量表(WAIS)。这些入院数据为回顾性调查HRB损伤与智商之间的关系提供了依据。研究发现,HRB损伤程度越高,全量表智商(FSIQ)得分越低(r = -0.78,p < .001)。当根据HRB表现将样本分为损伤组和正常组时,两个判别函数(即言语智商和图片排列)的系数对两组的分类准确率为100%。使用刀切法对逐步判别函数分析进行交叉验证,命中率为98%。本研究结果与其他两项近期研究结果表明,智力功能是解释慢性精神分裂症患者及其他精神疾病群体在HRB上表现的关键交互变量。文中讨论了在智力功能背景下解释功能损伤和正常功能时应注意的事项。

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