Imamura I, Maeyama K, Wada H, Watanabe T
Br J Pharmacol. 1984 Jul;82(3):701-7. doi: 10.1111/j.1476-5381.1984.tb10809.x.
A convenient and reproducible method for assay of imidazole acetic acid (ImAA) was developed as a modification of that described previously (Watanabe et al., 1983). ImAA conjugate(s) (ImAA-C), mainly consisting of imidazole acetic acid riboside, could be measured by this method after its hydrolysis to ImAA. The ImAA and ImAA-C levels in various tissues of rats were measured and the effects of various agents on these levels were studied. The renal clearance values of ImAA-C in rats and man were similar to the creatinine clearance values, but those of ImAA were 1/40 of those of ImAA-C, suggesting that the latter is readily excreted in the urine. Consistent with this idea, the urinary excretion of ImAA-C was found to increase much more than that of other histamine metabolites during late pregnancy, when the foetus produces much histamine.
作为对先前所述方法（渡边等人，1983年）的改进，开发了一种简便且可重复的咪唑乙酸（ImAA）测定方法。ImAA结合物（ImAA-C）主要由咪唑乙酸核糖苷组成，在水解为ImAA后可用该方法进行测定。测定了大鼠各种组织中的ImAA和ImAA-C水平，并研究了各种试剂对这些水平的影响。大鼠和人体中ImAA-C的肾清除率值与肌酐清除率值相似，但ImAA的肾清除率值是ImAA-C的1/40，这表明后者易于经尿液排泄。与这一观点一致的是，发现在妊娠后期胎儿产生大量组胺时，ImAA-C的尿排泄量比其他组胺代谢产物增加得更多。
