Gibson T, Rodgers A V, Simmonds H A, Toseland P
Br J Rheumatol. 1984 Aug;23(3):203-9. doi: 10.1093/rheumatology/23.3.203.
This study attempted to simulate the drinking habits of gout patients. Beer or squash was drunk over a 4-hour period on two successive days by five gouty and five normouricaemic men. Serum lactate increased with beer and squash, but elevation of plasma uric acid was confined to beer drinking. Urate clearance increased with both beverages, but 24-hour uric acid excretion was accentuated only by beer. The purine content of several beers was measured and the principal constituent found to be guanosine, which is probably the most readily absorbed dietary purine. It was concluded that the hyperuricaemic effect of beer was mediated by the digestion of purines contained by the beer and by an effect of ethanol on uric acid synthesis. There was no evidence that beer taken in usual quantities reduced the renal excretion of uric acid.
本研究试图模拟痛风患者的饮酒习惯。五名痛风患者和五名血尿酸正常的男性在连续两天的4小时内饮用啤酒或果汁饮料。饮用啤酒和果汁饮料后血清乳酸均升高，但血浆尿酸升高仅见于饮用啤酒后。两种饮料均使尿酸清除率增加，但仅啤酒使24小时尿酸排泄增加。测定了几种啤酒的嘌呤含量，发现主要成分是鸟苷，它可能是最易被吸收的膳食嘌呤。研究得出结论，啤酒的高尿酸血症作用是由啤酒中所含嘌呤的消化以及乙醇对尿酸合成的作用介导的。没有证据表明适量饮用啤酒会降低尿酸的肾脏排泄。
