Lemeignan M, Millart H, Lamiable D, Molgo J, Lechat P
Brain Res. 1984 Jun 18;304(1):166-9. doi: 10.1016/0006-8993(84)90875-8.
4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP) when injected intracisternally to anesthetized rats induced qualitatively similar central nervous system stimulant and convulsant effects at equimolar concentrations. Overall penetrability into cerebrospinal fluid of 4-AP is significantly higher than that of 3,4-DAP after single i.v. administration as evaluated by a high-performance liquid chromatographic determination. The present results can account for the lower central nervous system toxicity of 3,4-DAP when compared to 4-AP previously described after systemic administration.
当向麻醉大鼠脑池内注射4-氨基吡啶（4-AP）和3,4-二氨基吡啶（3,4-DAP）时，在等摩尔浓度下会诱导出定性相似的中枢神经系统兴奋和惊厥作用。通过高效液相色谱测定评估，单次静脉给药后，4-AP进入脑脊液的总体渗透率显著高于3,4-DAP。目前的结果可以解释与先前全身给药后描述的4-AP相比，3,4-DAP的中枢神经系统毒性较低的原因。
