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向无名质单侧注射加巴喷丁后杏仁核点燃惊厥的可逆性抑制

Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata.

作者信息

Okamoto M, Wada J A

出版信息

Brain Res. 1984 Jul 9;305(2):389-92. doi: 10.1016/0006-8993(84)90449-9.

DOI:10.1016/0006-8993(84)90449-9
PMID:6744074
Abstract

Amygdaloid kindled generalized convulsion was reversibly blocked despite continued afterdischarge generation by amygdaloid stimulation for about 60 h following intracerebral administration of gabaculine, a GABA-transaminase inhibitor, into the substantia innominata (SI) ipsilateral to the side of amygdaloid kindling. It is suggested that the SI plays an important role in convulsive seizure generalization of amygdaloid origin.

摘要

杏仁核点燃的全身性惊厥被可逆性阻断，尽管在向杏仁核点燃侧同侧的无名质（SI）脑内注射γ-氨基丁酸转氨酶抑制剂加巴喷丁后，杏仁核刺激持续产生后放电约60小时。这表明无名质在杏仁核起源的惊厥性发作泛化中起重要作用。

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