硫喷妥钠麻醉后大鼠尿中N-亚硝基二甲胺的排泄情况。
Urinary excretion of N-nitrosodimethylamine in rats after Thalamonal narcosis.
作者信息
Schmezer P, Klein R G, Spiegelhalder B
出版信息
Cancer Lett. 1984 Jul;23(3):351-3. doi: 10.1016/0304-3835(84)90103-4.
PMID:6744257
Abstract
Urinary excretion of N-nitrosodimethylamine (NDMA) in Sprague--Dawley rats was investigated after oral administration and inhalation of NDMA and concomitant narcosis by Thalamonal and diethyl ether. While ether anesthesia induced a 4-fold increase in the excretion rate, there was a drastic reduction (about 20-fold) in the amount of NDMA excreted after narcosis by Thalamonal.
摘要
在给斯普拉格-道利大鼠口服和吸入N-亚硝基二甲胺（NDMA）并同时使用复方镇痛药（Thalamonal）和乙醚麻醉后，对其尿液中N-亚硝基二甲胺的排泄情况进行了研究。虽然乙醚麻醉使排泄率提高了4倍，但使用复方镇痛药麻醉后，NDMA的排泄量急剧减少（约20倍）。
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