Bucher B, Travo P, Stoclet J C
Cell Biol Int Rep. 1984 Jul;8(7):567-77. doi: 10.1016/0309-1651(84)90056-0.
Changes in the smooth muscle cell compartment (SMCC) of the media layer of the aorta were studied in spontaneously hypertensive (SHR) and in normotensive rats (WKY) of both sexes between 3 to 18 weeks of age. Up to 7 weeks of age, development of the SMCC occurred in males and females of the two strains both through a massive increase in cell number and in cell size. In SHR after 7 weeks of age, the development of the SMCC was due to a marked increase in cell size together with an increase in cell number. In contrast during the same period, the development of the SMCC in WKY was associated almost exclusively with an increase in cell size. It is concluded that the presence of a greater number of larger smooth muscle cells contributes to the hypertrophy of the arterial wall of hypertensive animals.
在3至18周龄的自发性高血压大鼠（SHR）和正常血压大鼠（WKY）的两性中，研究了主动脉中层平滑肌细胞区室（SMCC）的变化。在7周龄之前，两个品系的雄性和雌性大鼠的SMCC发育都是通过细胞数量和细胞大小的大量增加来实现的。7周龄后，SHR中SMCC的发育是由于细胞大小的显著增加以及细胞数量的增加。相比之下，在同一时期，WKY中SMCC的发育几乎完全与细胞大小的增加有关。得出的结论是，大量较大的平滑肌细胞的存在导致了高血压动物动脉壁的肥厚。
