Phillipson C E, Ioannides C
Carcinogenesis. 1984 Aug;5(8):1091-4. doi: 10.1093/carcin/5.8.1091.
Dimethylnitrosamine, dipropylnitrosamine, methylethylnitrosamine, nitrosopiperidine and nitrosopyrrolidine were assayed for mutagenicity in the Ames test in the presence of hepatic postmitochondrial preparations isolated from the mouse, rat, hamster, pig and man. Prior to each mutagenicity assay all activation systems were fully characterised with respect to monoamine oxidase, mixed-function amine oxidase and mixed-function oxidase activities. The hamster was the most efficient activator for all nitrosamines followed by the mouse. The latter species, however, activated nitrosopyrrolidine only weakly which was the only carcinogen readily activated by the human preparation. None of the aliphatic nitrosamines was activated by the rat or pig. No correlation was observed between efficiency of activation and any of the enzyme activities studied.
在从老鼠、大鼠、仓鼠、猪和人类分离出的肝线粒体后制备物存在的情况下，对二甲基亚硝胺、二丙基亚硝胺、甲基乙基亚硝胺、亚硝基哌啶和亚硝基吡咯烷进行了Ames试验中的致突变性测定。在每次致突变性测定之前，所有激活系统都针对单胺氧化酶、混合功能胺氧化酶和混合功能氧化酶活性进行了充分表征。仓鼠是所有亚硝胺最有效的激活剂，其次是小鼠。然而，后一物种对亚硝基吡咯烷的激活作用很弱，而亚硝基吡咯烷是唯一能被人类制备物轻易激活的致癌物。大鼠或猪不能激活任何一种脂肪族亚硝胺。在所研究的酶活性与激活效率之间未观察到相关性。
