Meller Y, Kestenbaum R S, Yagil R, Shany S
Clin Orthop Relat Res. 1984 Jul-Aug(187):296-9.
In order to study age- and sex-related changes in calcium-regulating hormones, serum levels of parathormone (PTH), calcitonin (CT), and vitamin D metabolites were determined in 20 young dogs and 11 old dogs. A highly significant increase in serum levels of PTH was observed in old dogs (1.65 +/- 0.09 ng/ml versus 1.05 +/- 0.09 ng/ml in young animals) (p less than 0.001). Serum levels of 25-(OH)-D were significantly decreased in old dogs (11.24 +/- 2.03 ng/ml compared to 20.59 +/- 1.57 ng/ml in young dogs) (p less than 0.001). No significant differences in serum levels of 1,25-(OH)2-D, 24,25-(OH)2-D, and CT were found between young and old dogs. Serum CT levels were higher in males, especially in old animals. Young females had significantly higher serum levels of 25-(OH)-D than males. It seems that for some reason old dogs are in a relative state of vitamin D deficiency and hyperparathyroidism, which suggests the cause of skeletal alterations related to aging. A similar situation is observed in human geriatric patients.
为了研究钙调节激素与年龄和性别的相关变化，我们测定了20只幼犬和11只老龄犬血清中的甲状旁腺激素（PTH）、降钙素（CT）以及维生素D代谢产物的水平。老龄犬血清PTH水平显著升高（老龄犬为1.65±0.09 ng/ml，幼犬为1.05±0.09 ng/ml）（p<0.001）。老龄犬血清25-(OH)-D水平显著降低（老龄犬为11.24±2.03 ng/ml，幼犬为20.59±1.57 ng/ml）（p<0.001）。幼犬和老龄犬血清1,25-(OH)2-D、24,25-(OH)2-D以及CT水平无显著差异。雄性犬血清CT水平较高，尤其是老龄动物。年轻雌性犬血清25-(OH)-D水平显著高于雄性。似乎由于某种原因，老龄犬处于相对维生素D缺乏和甲状旁腺功能亢进状态，这提示了与衰老相关的骨骼改变的原因。在老年人类患者中也观察到类似情况。
