Connell J M, Ball S G, Inglis G C, Beastall G H, Davies D L
Clin Sci (Lond). 1984 Aug;67(2):219-23. doi: 10.1042/cs0670219.
The effect of low-dose dopamine infusion on anterior pituitary hormone secretion in a group of seven healthy female subjects is reported. Subjects were infused with NaCl solution (154 mmol/l) (control) or dopamine (0.01 and 0.1 micrograms min-1 kg-1 for 120 min at each rate) on separate days in the early follicular phase of consecutive menstrual cycles. Serum prolactin decreased during infusion of dopamine at 0.01 micrograms min-1 kg-1 but a similar fall was found in the control group. When the rate of dopamine infusion was increased to 0.1 micrograms min-1 kg-1 a further substantial decrease in prolactin concentration occurred, whereas prolactin in the control group showed no change. At the end of the period of dopamine infusion at 0.1 micrograms min-1 kg-1 serum prolactin remained significantly (P less than 0.025) lower than in the control group (85 +/- 12 vs 180 +/- 21 m-units/1). No change in thyrotrophin (TSH), growth hormone (GH) or luteinizing hormone (LH) was seen during either rate of dopamine infusion compared with control. While dopamine infusion at 0.1 micrograms min-1 kg-1 caused significant inhibition of prolactin secretion in normal female subjects, other pituitary hormone secretion was not affected: it is suggested that under the conditions of this study dopamine in hypophysial portal blood is not of primary importance in the control of basal TSH, GH and LH release.
本文报道了低剂量多巴胺输注对一组7名健康女性受试者垂体前叶激素分泌的影响。在连续月经周期的卵泡早期，受试者在不同日期分别输注氯化钠溶液（154 mmol/l）（对照组）或多巴胺（0.01和0.1微克·分钟⁻¹·千克⁻¹，各速率持续120分钟）。在以0.01微克·分钟⁻¹·千克⁻¹的速率输注多巴胺期间，血清催乳素水平下降，但对照组也出现了类似的下降。当多巴胺输注速率增加到0.1微克·分钟⁻¹·千克⁻¹时，催乳素浓度进一步大幅下降，而对照组的催乳素水平无变化。在以0.1微克·分钟⁻¹·千克⁻¹的速率输注多巴胺结束时，血清催乳素水平仍显著低于对照组（P＜0.025）（85±12对180±21 m单位/升）。与对照组相比，在任何一种多巴胺输注速率下，促甲状腺激素（TSH）、生长激素（GH）或黄体生成素（LH）均未发生变化。虽然以0.1微克·分钟⁻¹·千克⁻¹的速率输注多巴胺可显著抑制正常女性受试者的催乳素分泌，但其他垂体激素分泌未受影响：提示在本研究条件下，垂体门脉血中的多巴胺在基础TSH、GH和LH释放的控制中并非起主要作用。
