Brumfitt W, Hamilton-Miller J M
Chemotherapy. 1984;30(4):270-5. doi: 10.1159/000238279.
A combination of nitrofurantoin (100 mg) and sulphadiazine (300 mg) given 12-hourly for 7 days was used to treat 51 patients with recurrent urinary infections who were attending an out-patient clinic. Either nitrofurantoin or sulphadiazine was active in vitro against all the organisms isolated. The cure rate 1 week after the end of treatment was 82%; 10 patients relapsed during the following month, giving a cure rate 5 weeks after the end of treatment of 57%. Side effects, although relatively common (37%), were mild. The outcome of treatment with these two long-established drugs is thus as good as that obtained with some newer and more expensive preparations.
采用呋喃妥因（100毫克）和磺胺嘧啶（300毫克）联合用药，每12小时给药1次，持续7天，对51名前来门诊就诊的复发性尿路感染患者进行治疗。呋喃妥因或磺胺嘧啶在体外对所有分离出的病原体均有活性。治疗结束1周后的治愈率为82%；在接下来的一个月内，有10名患者复发，治疗结束5周后的治愈率为57%。副作用虽然相对常见（37%），但症状较轻。因此，这两种长期使用的药物的治疗效果与一些更新、更昂贵的制剂相当。
