Shizume K
Endocrinol Jpn. 1984 Apr;31(2):201-6. doi: 10.1507/endocrj1954.31.201.
The results of 6 months to 8 years of treatment of pituitary dwarfism in 1,959 patients in Japan were summarized. The data were based on the reports of the physicians treating the patients. Among the patients, 1,720 cases suffered from idiopathic pituitary dwarfism, 227 cases from secondary pituitary dwarfism, and 12 cases from unknown causes. Their initial age ranged from 9 months to 36 years old and their initial bone age ranged from 3 months to 15 years old. In most cases, a definite effect was observed. The effect was most remarkable during the initial 6 months and then declined gradually up to the fourth year. Males responded better than females. In younger and more immature patients, the effect was more remarkable. There were almost no side effects other than a few cases of impairment of capital femoral epiphysis.
总结了日本1959例垂体性侏儒症患者6个月至8年的治疗结果。数据基于治疗这些患者的医生的报告。患者中，1720例患有特发性垂体性侏儒症，227例患有继发性垂体性侏儒症，12例病因不明。他们的初始年龄为9个月至36岁，初始骨龄为3个月至15岁。在大多数情况下，观察到了确切的效果。效果在最初6个月最为显著，然后逐渐下降直至第4年。男性的反应比女性更好。在年龄较小、发育更不成熟的患者中，效果更显著。除了少数几例股骨头骨骺损伤外，几乎没有其他副作用。
