从大鼠尿液中分离并鉴定出八种丙环定代谢物。

Isolation and identification of eight procyclidine metabolites from rat urine.

作者信息

Paeme G, Grimee R, Vercruysse A

出版信息

Eur J Drug Metab Pharmacokinet. 1984 Apr-Jun;9(2):103-8. doi: 10.1007/BF03189612.

Abstract

After intraperitoneal administration of procyclidine, eight metabolites were isolated from rat urine. They were identified as 1-(4-oxocyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-(cis-4-hydroxycyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-(trans-4-hydrocyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol , (1R,3R,4S,7R)- and (1R,3R,4S,7S)-1-(cis-3,cis-4-dihydroxycyclohexyl)-1-phenyl-3-(1-py rrolidinyl)- 1-propanol, (1R,3R,4R,7R)- and (1R,3R,4R,7S)-1-(cis-3,trans-4-dihydroxycyclohexyl)-1-phenyl- 3-(1-pyrrolidinyl)-1-propanol, and one of both (1R,3S,4R,7R)- or (1R,3S,4R,7S)- 1-(trans-3,trans-4-dihydroxycyclohexyl)-1-phenyl-3-(1-pyrrolidinyl )-1-propanol by comparative TLC, GLC-MS and 13C-NMR spectroscopy.

摘要

腹腔注射丙环定后，从大鼠尿液中分离出8种代谢产物。通过比较薄层色谱法、气相色谱 - 质谱联用法和13C - 核磁共振光谱法，将它们鉴定为1 - (4 - 氧代环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇、1 - (顺式 - 4 - 羟基环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇、1 - (反式 - 4 - 氢环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇、(1R,3R,4S,7R)-和(1R,3R,4S,7S)-1 - (顺式 - 3,顺式 - 4 - 二羟基环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇、(1R,3R,4R,7R)-和(1R,3R,4R,7S)-1 - (顺式 - 3,反式 - 4 - 二羟基环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇，以及(1R,3S,4R,7R)-或(1R,3S,4R,7S)-1 - (反式 - 3,反式 - 4 - 二羟基环己基)-1 - 苯基 - 3 - (1 - 吡咯烷基)-1 - 丙醇中的一种。