Paeme G, Van Bossuyt H, Vercruysse A
Eur J Drug Metab Pharmacokinet. 1982;7(3):229-31. doi: 10.1007/BF03189569.
After pretreatment of adult male Wistar rats with phenobarbital, a well-known cytochrome P-450 inductor, the liver microsomal cytochrome P-450 content increased significantly compared to that of control rats. At the same time the amount of procyclidine, metabolized by the 9000 g supernatant fraction of rat liver homogenate fortified with a NADPH generating system, increased significantly as well. However when related to the liver microsomal cytochrome P-450 content, the amount of metabolized procyclidine does not differ anymore between phenobarbital treated and control rats. Therefore phenobarbital induces the in vitro metabolism of procyclidine.
用著名的细胞色素P - 450诱导剂苯巴比妥对成年雄性Wistar大鼠进行预处理后，与对照大鼠相比，肝脏微粒体细胞色素P - 450含量显著增加。同时，用添加了NADPH生成系统的大鼠肝脏匀浆9000g上清液部分代谢的丙环定数量也显著增加。然而，当与肝脏微粒体细胞色素P - 450含量相关时，苯巴比妥处理组和对照组大鼠代谢的丙环定数量不再有差异。因此，苯巴比妥诱导丙环定的体外代谢。
