Pedersen S, Sommer B, Nissen P
Eur J Respir Dis. 1984 Jul;65(5):354-61.
In a double-blind cross-over study, 20 children suffering from acute bronchoconstriction were treated with an interval of 90 min with placebo and 9.0 mg theophylline per kg given rectally in aqueous solution. Each child took part on 2 occasions. Fifteen min after both administrations of theophylline there was a significant increase in peak flow (PEF) as compared with placebo treatment (p less than 0.05). The increase in PEF was related to the serum level of theophylline, a significant bronchodilating effect was observed at about 7 mg/l. Substantial inter- and intrapatient variations were found in the improvement of PEF. The absorption of theophylline was rapid. The measured peak serum levels varied from 7.3 to 16.0 mg/l and occurred within 60 min in most patients. The intra-subject variations in the dose-to-dose absorption profiles were generally small and within a range acceptable for clinical use. The solutions allowed an accurate dosage calculation, did not initiate the urge to defecate, and were retained well.
在一项双盲交叉研究中，20名患有急性支气管收缩的儿童接受了治疗，每隔90分钟分别给予安慰剂和每公斤9.0毫克氨茶碱的直肠水溶液。每个儿童参与两次治疗。与安慰剂治疗相比，两次给予氨茶碱后15分钟，呼气峰值流速（PEF）均显著增加（p<0.05）。PEF的增加与氨茶碱的血清水平相关，在约7毫克/升时观察到显著的支气管舒张作用。在PEF改善方面发现了较大的患者间和患者内差异。氨茶碱吸收迅速。测得的血清峰值水平在7.3至16.0毫克/升之间，大多数患者在60分钟内达到峰值。受试者内剂量间吸收情况的差异通常较小，在临床应用可接受的范围内。该溶液便于精确计算剂量，不会引发便意，且保留良好。
