Vidyasagar T R
Exp Brain Res. 1984;55(1):192-5. doi: 10.1007/BF00240517.
The effect of iontophoretically applied bicuculline methiodide, an antagonist of GABA-mediated inhibition, was tested on the responses of cat dLGN neurones to moving lines. Most geniculate neurones normally show an orientation bias when tested with slowly moving long lines. This sensitivity to the orientation of the line stimulus could be markedly reduced during iontophoretic application of bicucullin. It is concluded that the orientation bias shown by geniculate neurones is to a large extent due to intrageniculate GABAergic inhibition.
通过离子电渗法施加GABA介导的抑制作用的拮抗剂甲磺酸荷包牡丹碱，测试其对猫背外侧膝状体（dLGN）神经元对移动线条反应的影响。大多数膝状体神经元在用缓慢移动的长线进行测试时通常表现出方向偏好。在离子电渗法施加荷包牡丹碱期间，这种对线条刺激方向的敏感性可能会显著降低。得出的结论是，膝状体神经元表现出的方向偏好很大程度上归因于膝状体内的GABA能抑制作用。
