Vidyasagar T R
Department of Neurobiology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany.
Neuroreport. 1992 Feb;3(2):185-8. doi: 10.1097/00001756-199202000-00016.
The orientation biases seen in the responses of neurones of the dorsal lateral geniculate nucleus (dLGN) can be reduced by the local application of the GABA antagonist, bicuculline methiodide. This fact was exploited to investigate whether these biases are important for cortical orientation selectivity by measuring the orientation sensitivity of cortical cells before and during iontophoretic administration of bicuculline in the topographically corresponding region of the dLGN. This procedure led to a significant reduction in the orientation sensitivity of the cortical cell. The results suggest that subcortical orientation biases are at least partly responsible for the orientation sensitivity seen at the level of the striate cortex.
通过局部应用GABA拮抗剂甲碘化荷包牡丹碱，可以降低外侧膝状体背核（dLGN）神经元反应中出现的方向偏向。利用这一事实，通过测量在dLGN地形对应区域离子电渗给予甲碘化荷包牡丹碱之前和期间皮质细胞的方向敏感性，来研究这些偏向对于皮质方向选择性是否重要。这一操作导致皮质细胞的方向敏感性显著降低。结果表明，皮质下方向偏向至少部分地导致了在纹状皮质水平所见的方向敏感性。
