Shiraishi T
Nihon Yakurigaku Zasshi. 1984 Feb;83(2):159-72.
The effects of mazindol on the salivary secretion of dogs was investigated. Mazindol (2 mg/kg, i.v.) decreased the volume and pressure of salivary secretion induced by either chemical (carpronium) stimulation or electrical nerve stimulation. It also reduced spontaneous salivary secretion. Secretion velocity in the mazindol treated group was significantly less than in the physiological saline administered control group at 4 to 6 min after injection. Saline and mazindol produced no significance differences in Na+, Cl- or K+ concentrations in the saliva or serum. Thus mazindol inhibition of salivary secretion was not caused by ion transport. The existence of some other inhibitory mechanism is suggested. The effects of mazindol on the peripheral and central control of gastric acid secretion was also investigated in rats. Gastric acid secretion induced by direct application of cholinergic agents on oxyntic cells was not affected by mazindol. Gastric acid secretion induced by insulin and/or 2-DG, on the other hand, was markedly inhibited by intra-hypothalamic injection or systemic (i.v.) injections of mazindol. Electro-osmotic mazindol mimicked the effects of glucose in the lateral (inhibition) and ventromedial (excitation) hypothalamus. The results suggest that the inhibitory effects of mazindol on salivary secretion may be through the hypothalamic feeding control centers. Mazindol also directly affected gastric acid secretory neurons in the lateral hypothalamus. It might thus be expected to be effective in the treatment of obesity.
研究了马吲哚对犬唾液分泌的影响。马吲哚（静脉注射2毫克/千克）可降低化学（卡普氯铵）刺激或电神经刺激诱导的唾液分泌量和压力。它还减少了自发性唾液分泌。注射后4至6分钟，马吲哚治疗组的分泌速度明显低于生理盐水给药对照组。生理盐水和马吲哚对唾液或血清中的Na +、Cl - 或K + 浓度没有显著差异。因此，马吲哚对唾液分泌的抑制不是由离子转运引起的。提示存在其他一些抑制机制。还研究了马吲哚对大鼠胃酸分泌的外周和中枢控制的影响。直接向壁细胞应用胆碱能药物诱导的胃酸分泌不受马吲哚影响。另一方面，胰岛素和/或2-脱氧葡萄糖诱导的胃酸分泌，经下丘脑内注射或全身（静脉）注射马吲哚后受到明显抑制。电渗马吲哚模拟了葡萄糖在下丘脑外侧（抑制）和腹内侧（兴奋）的作用。结果表明，马吲哚对唾液分泌的抑制作用可能通过下丘脑摄食控制中心。马吲哚还直接影响下丘脑外侧的胃酸分泌神经元。因此，预计它在治疗肥胖症方面可能有效。
