萘啶酸过量服用后出现乳酸酸中毒、高血糖和惊厥。
Lactic acidosis, hyperglycaemia and convulsions following nalidixic acid overdosage.
作者信息
Leslie P J, Cregeen R J, Proudfoot A T
出版信息
Hum Toxicol. 1984 Jun;3(3):239-43. doi: 10.1177/096032718400300308.
PMID:6745964
Abstract
A woman survived ingestion of 32 g nalidixic acid despite developing lactic acidosis, hyperglycaemia, convulsions and abnormal behaviour. The maximum recorded plasma concentration of nalidixic acid was 185 mg/l and the elimination half-life was 3.2 h. Carboxy-nalidixic acid was demonstrated in the plasma. Previously reported cases of nalidixic acid overdosage are reviewed.
摘要
一名女性摄入32克萘啶酸后存活下来，尽管出现了乳酸酸中毒、高血糖、惊厥和行为异常。萘啶酸的最高血浆浓度记录为185毫克/升，消除半衰期为3.2小时。血浆中检测到羧基萘啶酸。对先前报道的萘啶酸过量病例进行了综述。
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